Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Berberis species, particularly Berberis vulgaris (barberry), contain the alkaloid berberine, which has been investigated for its effects on lipid metabolism. Several clinical and preclinical studies suggest that berberine can modulate fat metabolism, notably by activating AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance. This activation has been associated with improved lipid profiles, including reductions in total cholesterol, LDL cholesterol, and triglycerides. Some randomized controlled trials have shown that berberine supplementation can lead to modest but statistically significant improvements in dyslipidemia and metabolic syndrome parameters.

However, the overall quality and quantity of evidence is moderate. Most clinical studies are small, short-term, or use berberine rather than whole Berberis extracts. The traditional use of Berberis in herbal medicine has focused more on liver, digestive, and antimicrobial indications rather than directly targeting fat metabolism or lipid disorders. Thus, while there is a scientific basis for berberine (a major constituent of Berberis) supporting fat metabolism, the evidence is not robust, and more large-scale, long-term human studies are needed to confirm efficacy and safety.

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