Evidence supporting the use of: Hydroxycitric acid
For the health condition: Fat Cravings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydroxycitric acid (HCA) is a compound extracted primarily from the rind of the Garcinia cambogia fruit, and it is most commonly marketed as a weight loss and appetite-suppressing supplement. The rationale for its use in supporting or treating fat cravings stems from its proposed ability to inhibit the enzyme ATP-citrate lyase, which is involved in converting carbohydrates into fat in the body. Inhibition of this enzyme is theorized to reduce fat accumulation and possibly decrease appetite or cravings for fatty foods. Several animal and human studies have investigated the effects of HCA on appetite and food intake. Some small, short-term clinical trials have reported modest reductions in appetite and food consumption, including cravings for fatty foods, among participants taking HCA supplements. For instance, a few studies observed minor decreases in caloric intake and self-reported hunger when HCA was administered prior to meals. However, other well-conducted randomized controlled trials have failed to find significant effects on appetite, cravings, or weight loss compared to placebo. A 2011 meta-analysis published in the Journal of Obesity concluded that the overall effect of HCA on weight loss and appetite suppression is small and of questionable clinical relevance. The evidence to support its specific use for treating fat cravings is therefore limited and inconsistent. While there is a scientific rationale for its use, the overall strength of evidence is weak (rated 2/5), and more robust, long-term studies are needed to establish clear efficacy for this purpose.

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