Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Zeaxanthin is a carotenoid pigment found in high concentrations within the macula of the human retina. Scientific research supports its use for eye health, particularly in relation to age-related macular degeneration (AMD). Numerous epidemiological and clinical studies—including randomized controlled trials—have investigated the role of zeaxanthin (often alongside lutein) in supporting visual function and protecting against AMD progression. The Age-Related Eye Disease Study 2 (AREDS2), a large, multi-center clinical trial, found that supplementation with lutein and zeaxanthin can reduce the risk of progression to advanced AMD in individuals at high risk. Mechanistically, zeaxanthin acts as an antioxidant and helps filter harmful high-energy blue light, thus protecting retinal cells from oxidative stress and light-induced damage.

While most studies focus on zeaxanthin in combination with lutein, the specific role of zeaxanthin has been increasingly recognized, given its higher concentration in the central macula (fovea) compared to lutein. Scientific consensus indicates that dietary intake or supplementation of zeaxanthin can increase the macular pigment optical density, which is associated with improved visual performance and possible reduction in the risk of AMD. However, while evidence is strong for AMD risk reduction, there is less direct evidence for other eye conditions.

In summary, there is substantial scientific validation for zeaxanthin’s use in supporting the eye, particularly for macular health and protection against age-related degeneration, earning a high evidence rating.

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Products containing zeaxanthin

Nature's Sunshine Lutein
Nature's Sunshine Perfect Eyes