Evidence supporting the use of: Oligomeric proanthocyanidins
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oligomeric proanthocyanidins (OPCs) are polyphenolic compounds found in various plants, notably grape seeds and pine bark. Their use to support eye health is based on their potent antioxidant properties, which can help protect ocular tissues from oxidative stress—a key factor in the development of age-related eye disorders such as macular degeneration and cataracts. Several in vitro and animal studies have shown that OPCs can inhibit oxidative damage to retinal cells and improve microcirculation in ocular tissues. For example, research published in Ophthalmic Research (2005) demonstrated that grape seed proanthocyanidin extract reduced retinal oxidative stress in diabetic rats.

Small clinical studies and some trials—such as those using Pycnogenol® (a standardized pine bark extract)—have suggested that OPCs may help improve symptoms of diabetic retinopathy by reducing capillary leakage and improving visual function. However, the evidence in humans remains limited, with most studies being small, short-term, or lacking rigorous controls. No large-scale randomized controlled trials have definitively established OPCs as effective eye health supplements. Therefore, while there is some scientific rationale and preliminary data supporting their use for eye health, the strength of evidence is moderate at best, and further research is necessary to confirm efficacy and determine optimal dosing.

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Other body systems supported by Oligomeric proanthocyanidins

Arteries
Blood
Brain
Capillaries
Circulatory System
Eyes
Gums
Heart
Immune System
Skin
Veins

Products containing Oligomeric proanthocyanidins

We currently have no products on Caring Sunshine that contain this ingredient.