Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-carnosine is a naturally occurring dipeptide composed of beta-alanine and histidine. Its use in supporting the eye, particularly in the context of age-related conditions like cataracts, has some scientific basis. Research, primarily from Eastern Europe and Russia, has investigated the use of topical N-acetylcarnosine (a derivative of carnosine) eye drops for delaying the progression of cataracts. Several small, randomized controlled trials have reported that these eye drops can improve lens clarity and visual acuity in patients with cataracts, presumably due to carnosine’s antioxidant and anti-glycation properties. Carnosine may help neutralize reactive oxygen species and inhibit protein cross-linking, processes implicated in cataract formation.

However, the quality of evidence is limited. Most studies have small participant numbers, short durations, and are sometimes criticized for lacking rigorous blinding or being conducted by a limited number of research groups. Systematic reviews have concluded that while early results are promising, larger, high-quality trials are needed to confirm efficacy and safety. Oral supplementation of L-carnosine for eye health is less studied; most research focuses on topical application. There is little traditional or historical use of carnosine for eye health—it is a relatively modern intervention based on biochemical rationale.

In summary, there is moderate scientific evidence (particularly for topical use) supporting L-carnosine’s benefit for certain eye conditions, though further research is warranted.

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