Evidence supporting the use of: Zeaxanthin
For the health condition: Eye Problems

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Zeaxanthin is a carotenoid pigment found in high concentrations in the macula of the human retina, where it plays a key role in visual function and protection against light-induced oxidative damage. Scientific evidence supports its use for eye health, particularly in reducing the risk of age-related macular degeneration (AMD). Multiple epidemiological studies, such as the Age-Related Eye Disease Study 2 (AREDS2), have demonstrated that supplementation with zeaxanthin (often combined with lutein) is associated with a decreased risk of progression to advanced AMD in individuals at high risk. The mechanism involves zeaxanthin’s antioxidant properties and its ability to filter high-energy blue light, thereby protecting retinal cells from oxidative stress and potential damage.

Additionally, intervention trials and meta-analyses have reported improved macular pigment optical density and, in some cases, modest improvements in visual performance (e.g., contrast sensitivity) following zeaxanthin supplementation. However, while evidence is relatively strong for slowing AMD progression, there is less direct evidence supporting zeaxanthin for other eye conditions such as cataracts or general visual improvement in healthy individuals. Overall, current clinical guidelines support the use of zeaxanthin-containing supplements for patients at risk of AMD, but not necessarily for the general population or for other eye diseases.

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