Evidence supporting the use of: Trichosanthes
For the health condition: Eye Problems

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Trichosanthes, particularly Trichosanthes kirilowii and Trichosanthes cucumerina, has a long history of use in traditional Chinese medicine (TCM) and other Asian medical systems. In these traditions, extracts from the plant’s fruit, root, or seeds—often referred to as “gua lou”—have been used for a variety of ailments. Specifically, some classical TCM texts mention its use to “clear heat” and “moisten dryness,” which, in older medical paradigms, could be extended to conditions affecting the eyes such as dryness, redness, or inflammation. Preparations may be included in formulas intended to treat visual disturbances or eye discomfort, especially when believed to be related to internal heat or phlegm. However, there is very limited modern scientific research directly investigating the efficacy of Trichosanthes for ophthalmic (eye) conditions. Most available studies focus on its potential anti-inflammatory, antioxidant, and immunomodulatory effects in general. These properties could, in theory, confer some benefit for inflammatory eye conditions, but direct clinical evidence is lacking. As a result, the use of Trichosanthes for eye problems is primarily justified by traditional practice, rather than contemporary scientific validation. The overall quality of evidence supporting its use for eye problems is weak (rated 1/5), and those interested in its use for ocular health should consult a qualified healthcare provider and not substitute it for evidence-based treatments.

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