Silica hypromellose, more commonly referred to as hypromellose or hydroxypropyl methylcellulose (HPMC), is widely used as a lubricant in artificial tear preparations for dry eye and other ocular surface disorders. The “silica” in some commercial preparations refers to colloidal silica, which acts as a thickening agent or stabilizer, but it is the hypromellose that provides the therapeutic benefit. Hypromellose is a semi-synthetic, inert, viscoelastic polymer that forms a lubricating film over the cornea and conjunctiva, mimicking the function of natural tears and alleviating discomfort associated with dry eyes, irritation, or exposure keratitis.

Multiple clinical studies and systematic reviews support the efficacy and safety of hypromellose-based eye drops in relieving symptoms of dry eye syndrome and maintaining ocular surface moisture. Hypromellose has been shown to reduce ocular surface staining, improve tear film stability, and enhance patient comfort. It is included in numerous guideline recommendations for the management of dry eye disease and is approved by regulatory agencies worldwide for this purpose. The evidence is strong (rated 5/5), with decades of clinical use and a robust body of published research supporting its role in eye care.

In summary, the use of hypromellose (sometimes combined with silica as a stabilizer) to treat or support eye problems, particularly dry eye, is scientifically justified and well-validated.