Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Hydroxypropyl cellulose is scientifically validated for use in treating certain eye problems, particularly as an ocular lubricant for dry eyes (keratoconjunctivitis sicca). It is the active ingredient in several FDA-approved ophthalmic products such as Lacrisert, which is a prescription insert placed in the lower eyelid. Numerous clinical studies have demonstrated that hydroxypropyl cellulose can relieve symptoms of dryness, irritation, and discomfort by supplementing the tear film and providing prolonged moisture to the ocular surface. Its mechanism of action involves forming a viscoelastic, clear film over the cornea, which reduces tear evaporation and protects the eye. Hydroxypropyl cellulose is well-tolerated, with few adverse effects reported in clinical use. The American Academy of Ophthalmology and other professional organizations recognize it as an effective treatment option for moderate to severe dry eye disease, especially in cases where artificial tears are insufficient. Its efficacy and safety profile are supported by placebo-controlled trials and decades of clinical experience, making it a mainstay in the management of chronic dry eye conditions.

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