Evidence supporting the use of: Immunoglobulins
For the health condition: Eye Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Immunoglobulins, particularly immunoglobulin preparations for topical or systemic use, have a scientific basis for their use in certain eye infections, though this is not a widespread or first-line therapy. Immunoglobulins are antibodies that can neutralize pathogens, and their use is most prominent in individuals with immune deficiencies or in specific severe infections where conventional treatments may not suffice. For example, topical or subconjunctival immunoglobulin therapy has been explored in the treatment of viral and bacterial keratitis or conjunctivitis, especially in cases resistant to standard therapy or in patients with impaired immune responses (e.g., those with hypogammaglobulinemia). Several clinical studies and case reports have documented beneficial outcomes, particularly with pooled human immunoglobulin (IVIG) applied locally to the ocular surface, showing reduced severity and duration of infection in some viral cases such as herpes simplex keratitis and adenoviral conjunctivitis. However, the overall strength of evidence remains moderate (rated 3), as large-scale randomized controlled trials are lacking, and the use is mostly limited to special circumstances or compassionate use cases. Current ophthalmic guidelines do not generally recommend immunoglobulins as standard therapy for routine eye infections but acknowledge their potential role in refractory or immunocompromised cases. Thus, while immunoglobulins are not a traditional remedy, their use is grounded in scientific rationale and supported by moderate-level clinical evidence in select scenarios.

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