Genipap (Genipa americana) has a history of use in traditional medicine among indigenous peoples in South America, including applications for various ailments. Regarding eye infections, there are ethnobotanical reports indicating that some communities have used genipap preparations (such as decoctions or infusions) for topical application to treat conjunctivitis or other eye irritations. However, these uses are based largely on tradition and anecdotal accounts rather than robust scientific investigation.

Scientific studies examining the efficacy of genipap specifically for eye infections are lacking. While genipap fruit and leaves contain compounds with reported antimicrobial and anti-inflammatory properties, such as iridoids and polyphenols, there is no direct clinical or preclinical evidence demonstrating effectiveness or safety of genipap in treating ocular infections. As such, the traditional use may be informed by the plant's general medicinal reputation, but there is a significant gap in evidence-based validation for this specific application.

In summary, the use of genipap for eye infections is primarily rooted in traditional medicine, with minimal scientific support at present. Caution is warranted given the lack of rigorous studies on efficacy or ocular safety.