Evidence supporting the use of: Growth factors
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Growth factors, such as IGF-1 (Insulin-like Growth Factor-1), fibroblast growth factors (FGFs), and other peptide growth factors, have been scientifically investigated for their roles in muscle repair, regeneration, and adaptation following exercise. These factors are naturally released in response to physical activity and are involved in processes like cell proliferation, differentiation, and tissue remodeling. Scientific studies, particularly in animal models and cell cultures, have demonstrated that growth factors can enhance muscle hypertrophy, promote satellite cell activation, and accelerate recovery from muscle injuries induced by intense exercise.

In human research, exogenous administration of growth factors (such as IGF-1) is less common due to potential safety and ethical concerns, but some clinical trials and observational studies have shown increased local expression of growth factors in exercised muscles, correlating with improved adaptation or recovery. Additionally, therapies like platelet-rich plasma (PRP), which are rich in various growth factors, are sometimes used to support recovery from sports injuries, though results are mixed and still under investigation.

Overall, while there is substantial mechanistic evidence supporting the importance of growth factors in exercise adaptation and recovery, the direct therapeutic use of purified or recombinant growth factors in healthy individuals for exercise support is not yet widely adopted or recommended outside specific medical scenarios. Thus, the evidence supporting their supplementation or exogenous administration for general exercise enhancement is moderate, meriting a rating of 3.

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