Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glutamine is a non-essential amino acid that plays an important role in immune function and gut health. Its use as a supplement to support or enhance exercise recovery and performance is based on some biological rationale: intense exercise can lower plasma glutamine levels, and immune suppression post-exercise has been linked to decreased glutamine availability. However, the scientific evidence supporting glutamine supplementation for exercise is limited and inconsistent. Most studies in healthy, well-nourished athletes have failed to show significant benefits for muscle recovery, muscle soreness, strength gains, or prevention of exercise-induced immune suppression. Some small studies have suggested possible benefits in reducing infection risk in overtrained athletes or in very specific, extreme endurance scenarios, but the effects are not robust or consistent across research. Systematic reviews and meta-analyses generally conclude that glutamine supplementation does not significantly enhance exercise performance or recovery in the general athletic population. Therefore, while there is some scientific rationale and limited evidence in specific contexts, glutamine is not broadly validated for exercise support or treatment.

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