Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dipeptides, which are molecules consisting of two amino acids joined by a peptide bond, have garnered some scientific interest in the context of exercise support and recovery. Specific dipeptides, such as carnosine (β-alanyl-L-histidine), have been researched for their potential to enhance exercise performance, particularly during high-intensity activities. Carnosine acts as an intracellular buffer, helping to delay the onset of muscle fatigue by buffering hydrogen ions that accumulate during intense exercise. Several studies have shown that supplementation with beta-alanine (a precursor to carnosine) can increase muscle carnosine concentrations and subsequently improve high-intensity exercise capacity and reduce fatigue in athletes. However, the evidence is more limited for "unspecified" dipeptides, as the effects are highly dependent on the particular amino acids involved and their physiological roles. While some dipeptides have demonstrated bioactivity and potential ergogenic effects, the majority of research focuses on well-characterized compounds like carnosine rather than dipeptides as a broad category. The use of dipeptides as supplements is sometimes justified by their potentially superior absorption compared to free amino acids. In summary, there is scientific interest and some evidence supporting the use of specific dipeptides (notably carnosine) for exercise performance. However, for "unspecified" dipeptides, the evidence is less robust, and broad claims about their effectiveness for exercise are not strongly supported by current research. Thus, the overall evidence rating is modest.

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