Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coenzyme Q10 (CoQ10) is a fat-soluble compound that plays a critical role in mitochondrial energy production, and its supplementation has been studied for its potential to enhance exercise performance and recovery. The scientific rationale for using CoQ10 in exercise is based on its role as an electron carrier in the mitochondrial electron transport chain, which is essential for ATP production—the energy currency required for muscle contraction during physical activity. Additionally, CoQ10 functions as an antioxidant, helping to mitigate oxidative stress that can increase during intensive exercise.

Several clinical trials and meta-analyses have explored the effects of CoQ10 supplementation on exercise performance. Some studies have reported modest improvements in exercise capacity, VO2 max, and reduced fatigue, particularly in untrained or older individuals, or those with lower baseline CoQ10 levels. However, results are mixed; other trials find little to no benefit in healthy, well-trained athletes. The variability in findings may be due to differences in study design, dosing, duration, and participant characteristics.

On balance, while there is a plausible biological mechanism and some supportive evidence, the quality and consistency of clinical data are moderate. It is not a traditional remedy for exercise support, but rather an area of modern scientific interest. CoQ10 is generally considered safe, and some athletes and active individuals may use it with the hope of modest benefits, but it should not be considered a proven ergogenic aid for all populations.

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