Evidence supporting the use of: Boron (various)
For the health condition: Estrogen (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Boron has some scientific evidence supporting its use in influencing estrogen levels, though the evidence is preliminary and limited. A few small clinical studies and animal research have shown that boron supplementation can increase serum levels of estradiol (a key estrogen) in both postmenopausal women and men. For example, a study by Naghii et al. (2011) found that supplementation with 6 mg of boron daily for one week in healthy men led to a significant increase in plasma estradiol and a decrease in sex hormone-binding globulin (SHBG), which could theoretically increase bioavailable estrogen. In postmenopausal women, similar short-term studies have reported increased estradiol levels after boron supplementation. The proposed mechanisms involve boron's influence on steroid hormone metabolism, possibly by affecting enzymes involved in the synthesis and metabolism of estrogen. However, these findings are based on short-duration, small-sample studies, and there is limited data on long-term safety or efficacy, especially in clinically estrogen-deficient populations. Major health authorities do not currently recommend boron as a treatment for low estrogen, and more robust clinical trials are needed to establish its role. Thus, while there is some scientific basis for boron’s effect on estrogen metabolism, the quality and quantity of evidence supporting its use for treating low estrogen are limited, justifying a modest evidence rating.

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Products containing Boron (various)

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