Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. Its use to support the estrogen body system is based on a growing body of scientific evidence, particularly from in vitro, animal, and some human studies. I3C is known to modulate estrogen metabolism in the body by promoting the conversion of estrogen to less active metabolites, specifically increasing the ratio of 2-hydroxyestrone to 16α-hydroxyestrone. This shift is considered beneficial because 2-hydroxyestrone is thought to be less estrogenic and potentially protective against estrogen-sensitive cancers, such as those of the breast and cervix.

Clinical studies have demonstrated that I3C supplementation can alter estrogen metabolism in humans, with several small trials suggesting a potential benefit in reducing the risk of certain hormone-dependent cancers. For example, some research in women with cervical dysplasia and breast cancer survivors has shown favorable changes in estrogen metabolite ratios after I3C supplementation. However, the sample sizes are generally small, and long-term clinical outcome data are still limited.

Overall, while there is a plausible biological mechanism and some supportive clinical data, the evidence is not yet robust enough to warrant the highest rating. The use of I3C for estrogen support is scientifically justified but remains an area of active research.

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Nature's Sunshine Indole-3-Carbinol