Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Genistein is an isoflavone found predominantly in soy products and is classified as a phytoestrogen due to its structural similarity to 17β-estradiol, the primary estrogen hormone in humans. Its use to support the estrogen body system is primarily based on its ability to bind to estrogen receptors, particularly the beta subtype, and exert weak estrogenic or anti-estrogenic effects depending on endogenous estrogen levels.

Multiple studies, including randomized controlled trials and meta-analyses, have investigated genistein’s impact on menopause-associated symptoms such as hot flashes, bone density, and cardiovascular health. For example, a 2015 meta-analysis in Menopause found that genistein supplementation modestly reduced the frequency and severity of hot flashes in postmenopausal women. Other research has indicated potential benefits in bone health and lipid profiles, although results are mixed and the magnitude of effect is generally moderate.

Despite promising findings, the evidence is not uniformly strong, with some studies reporting minimal or no benefit. Moreover, concerns remain about long-term safety, particularly in women with a history of estrogen-sensitive cancers, though most short-term studies report few adverse effects.

In summary, there is scientific evidence supporting the use of genistein for certain menopause-related symptoms, but the strength and consistency of the evidence are moderate (rating: 3), and further high-quality research is needed.

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