Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Equol is a metabolite produced from the isoflavone daidzein by intestinal bacteria, primarily after the consumption of soy products. It is known for its ability to bind to estrogen receptors, especially estrogen receptor beta (ERβ), with higher affinity than its precursor isoflavones. Scientific interest in equol centers around its potential to modulate symptoms related to estrogen deficiency, such as those experienced during menopause (hot flashes, bone loss, etc.). Some studies, including randomized controlled trials, indicate that equol supplementation may help reduce vasomotor symptoms in postmenopausal women, improve skin health, and support bone health by mimicking some of the effects of estrogen. However, the strength of the evidence is moderate rather than robust; not all studies consistently show benefit, and effects may depend on whether an individual is an "equol producer" (can naturally convert daidzein into equol). Despite this, equol is increasingly included in supplements aimed at estrogen support due to its selective estrogen receptor modulator (SERM)-like properties and generally favorable safety profile. Nevertheless, long-term safety and efficacy data are limited, and more large-scale clinical trials are needed to confirm its benefits and clarify its role in estrogen-related health.

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