Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Daidzin is an isoflavone glycoside found primarily in soybeans and other legumes. Its use to support the estrogen body system is rooted mainly in traditional and ethnobotanical practices, particularly in East Asian cultures where soy-based foods are dietary staples. Daidzin, along with other soy isoflavones such as genistin and glycitin, is classified as a phytoestrogen—a plant compound that can weakly mimic the action of endogenous estrogens by binding to estrogen receptors. Historically, populations consuming diets high in soy have been observed to have lower rates of menopausal symptoms and certain hormone-related diseases, which has led to the traditional belief that soy isoflavones can support estrogen-related functions in the body. However, direct clinical evidence specifically for daidzin’s effect on the estrogen system is limited, as most studies focus on the broader class of soy isoflavones or on aglycones such as daidzein (the metabolite of daidzin). Some in vitro and animal research indicates phytoestrogens may exert a mild estrogenic or anti-estrogenic effect depending on hormonal milieu and receptor subtype, but human studies are inconsistent and often underpowered. Thus, while traditional use and some mechanistic rationale exist, robust scientific validation of daidzin itself for estrogen support is lacking, justifying a moderate evidence rating.

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