Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine malate is sometimes used to support erectile dysfunction (ED) based primarily on its L-arginine component. L-arginine is an amino acid that serves as a precursor to nitric oxide (NO), a molecule that plays a key role in vasodilation and blood flow, both of which are important for achieving and maintaining erections. Several clinical studies have investigated L-arginine supplementation for ED, with mixed results. Some small trials have shown that L-arginine (often at high doses, e.g., 5 grams daily) can improve ED symptoms, especially in men with low baseline nitric oxide activity. However, effects tend to be modest and may be enhanced when combined with other supplements (e.g., pycnogenol).

Specific evidence for "arginine malate" (as opposed to L-arginine alone) is much less robust. Malate is a salt form added to improve absorption, but it does not have independent evidence supporting a role in ED. There is no well-established body of traditional use for arginine malate in the context of sexual health. The scientific evidence thus relates to L-arginine itself and is considered weak to moderate, with most guidelines not recommending L-arginine as a first-line ED treatment. In summary, arginine malate's use for ED is based on a plausible scientific mechanism and some clinical data for L-arginine, but overall, the evidence is limited and does not strongly support its routine use.

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