Evidence supporting the use of: Arginine-L-malate
For the health condition: Erectile Dysfunction

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine-L-malate is a compound consisting of the amino acid L-arginine and malic acid. L-arginine is a well-studied precursor to nitric oxide, which plays a critical role in vasodilation and blood flow, mechanisms relevant to erectile function. Several clinical studies have investigated L-arginine supplementation for erectile dysfunction (ED), with mixed but generally positive results, especially in cases with endothelial dysfunction or mild ED. The evidence primarily supports L-arginine itself, rather than specifically Arginine-L-malate, but the rationale for the malate form is that it may improve absorption or cellular energy, though this is less well studied.

There is some scientific support for using L-arginine in ED, with meta-analyses and clinical trials indicating modest improvements in erectile function compared to placebo. However, most studies use L-arginine alone or in combination with other ingredients (e.g., pycnogenol), not specifically Arginine-L-malate. There is little to no direct clinical evidence regarding Arginine-L-malate as a distinct compound for ED. The malate component has no established role in erectile function, though it is involved in the Krebs cycle and energy production.

In summary, scientific rationale and evidence exist for L-arginine supplementation in ED, but direct evidence for Arginine-L-malate is limited. The rating reflects the indirect support for the malate form based on L-arginine studies and the theoretical benefits of malic acid, but more research specific to Arginine-L-malate is needed.

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