Evidence supporting the use of: Reishi mushroom
For the health condition: Epstein Barr Virus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Reishi mushroom (Ganoderma lucidum) has a long history of use in traditional Chinese medicine for enhancing immune function and promoting general health. Regarding Epstein-Barr Virus (EBV), which is a herpesvirus associated with infectious mononucleosis and several chronic conditions, the interest in reishi stems from its immunomodulatory and antiviral properties. Laboratory studies have shown that reishi contains various bioactive compounds, such as polysaccharides and triterpenes, which can modulate immune responses by enhancing the activity of natural killer cells and increasing the production of certain cytokines. Some in vitro and animal studies suggest that these compounds may help inhibit viral replication or boost the body’s ability to control chronic viral infections, including herpesviruses. However, direct clinical evidence that reishi treats or significantly supports recovery from EBV in humans is currently limited. Most of the available data come from preclinical studies or indirect evidence, such as its effects on related herpesviruses or general immune enhancement. No large, well-controlled human trials specifically investigating reishi’s effects on EBV infection or reactivation have been published as of 2024. Therefore, while the scientific rationale for its use exists and is supported by early-stage research, the overall evidence is weak and primarily theoretical or extrapolated from broader immunological effects. As such, reishi may be considered as a supportive adjunct, but not a primary treatment, for EBV, and more robust clinical trials are needed.

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