Evidence supporting the use of: Vitamin B6
For the body system: Epinephrine
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B6 (pyridoxine) plays a key role in the synthesis of several neurotransmitters, including epinephrine (also known as adrenaline). The conversion of the amino acid tyrosine to epinephrine involves multiple enzymatic steps. One of these steps is the decarboxylation of L-dopa to dopamine, catalyzed by the enzyme aromatic L-amino acid decarboxylase, which requires pyridoxal phosphate (the active form of vitamin B6) as a cofactor. Dopamine is subsequently converted to norepinephrine and then to epinephrine. Thus, vitamin B6 is biochemically essential for the endogenous production of epinephrine. However, while vitamin B6 deficiency can impair neurotransmitter synthesis and potentially reduce epinephrine production, there is limited direct evidence that vitamin B6 supplementation in individuals with adequate nutritional status will enhance epinephrine levels or have significant effects on the "epinephrine body system" in healthy people. Most of the scientific evidence comes from biochemical and animal studies, as well as rare clinical cases of severe B6 deficiency. There is little evidence from clinical trials supporting the use of B6 supplements specifically to boost epinephrine or its physiological effects in the general population. Therefore, while the biochemical rationale is clear, practical supplementation for this purpose is only justified in the context of deficiency.
Other ingredients that support Epinephrine
caffeinel-tyrosine
Acetyl-L-Tyrosine
vitamin B6
Adrenergic amines
Adrenaline
Catecholamine
Ephedra
Ephedrine
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