Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Caffeine is scientifically validated as a compound that influences the epinephrine (adrenaline) body system. Its primary mechanism involves antagonism of adenosine receptors in the central nervous system, which leads to increased neuronal firing and the subsequent release of neurotransmitters, including epinephrine. Numerous studies have shown that caffeine consumption results in elevated plasma levels of epinephrine, leading to physiological effects such as increased heart rate, enhanced alertness, and improved physical performance. This is particularly relevant in the context of exercise, where caffeine-induced epinephrine release contributes to increased lipolysis and energy availability.

Clinical research consistently demonstrates these effects, with caffeine doses commonly used in studies (about 3–6 mg/kg body weight) reliably increasing circulating epinephrine. The World Anti-Doping Agency (WADA) previously monitored caffeine due to its ergogenic effects, which are partly attributed to stimulation of the epinephrine system. However, while caffeine supports the epinephrine system acutely, chronic excessive use can lead to tolerance and adverse effects. The evidence base includes both controlled clinical trials and well-understood physiological mechanisms. Thus, its use to support the epinephrine system is justified by scientific validation.

More about caffeine
More about Epinephrine

Other ingredients that support Epinephrine

Other body systems supported by caffeine

Products containing caffeine