Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Ketones, specifically in the form of a ketogenic diet (which induces ketosis and elevates blood ketone levels), have substantial scientific support for their use in the management of epilepsy, particularly in drug-resistant cases. The ketogenic diet is a high-fat, low-carbohydrate dietary regimen that shifts the body’s metabolism toward fat utilization, resulting in the production of ketone bodies (acetoacetate, beta-hydroxybutyrate, and acetone). These ketones are thought to provide an alternative energy source for neurons and may exert anticonvulsant effects through multiple mechanisms, including enhanced mitochondrial function, modulation of neurotransmitter balance, and reduction of neuronal excitability.

Clinical studies, including randomized controlled trials and meta-analyses, have shown that the ketogenic diet can reduce seizure frequency in both children and adults with refractory epilepsy. The most robust evidence supports its use in pediatric populations, where up to 50% of children experience a significant reduction in seizure frequency. While the exact mechanism is not fully understood, the consistent clinical benefit has led to widespread acceptance of ketogenic therapies in epilepsy management guidelines. Exogenous ketones (supplements) are a newer area of research, with some early evidence suggesting potential benefits, but the primary clinical evidence supports the dietary approach. Overall, the use of ketones for epilepsy is scientifically validated, especially where standard medications have failed.

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