Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutamine is an amino acid that serves as a primary fuel source for enterocytes (cells lining the intestine). Its use in supporting or treating enteritis is based on a moderate body of scientific evidence, primarily from clinical and preclinical studies. Glutamine supplementation has been shown to help maintain the integrity of the intestinal mucosa, support immune function, and reduce intestinal permeability, which are important in the context of enteritis, a condition characterized by inflammation of the intestine.

Several randomized controlled trials and meta-analyses have investigated oral and parenteral glutamine supplementation in patients with various forms of enteritis, including those related to chemotherapy, radiation, and critical illness. Many of these studies report positive outcomes, such as reduced severity and duration of diarrhea, improved gut barrier function, and decreased infection rates. However, results are inconsistent, and some trials have not demonstrated significant clinical benefit, especially in large, heterogeneous populations.

Current clinical guidelines do not universally recommend glutamine for all cases of enteritis, but its use may be considered in specific populations, such as patients with severe mucositis or those undergoing particular cancer therapies. The overall evidence supports a moderate benefit, and ongoing research continues to clarify optimal patient populations and dosing strategies.

In summary, glutamine has a plausible biological rationale and some scientific validation for use in enteritis, but further high-quality studies are needed to establish its efficacy in broader clinical practice.

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