Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacillus clausii is a probiotic bacterium widely used in the management of enteritis, particularly in cases of acute diarrhea and antibiotic-associated diarrhea in both children and adults. Its use is supported by a growing body of scientific evidence, although large-scale, high-quality randomized controlled trials are still limited, which is why the evidence rating is moderate (3/5).

Several clinical studies have demonstrated that B. clausii can help restore intestinal microbiota balance disrupted by infections or antibiotic therapies. It is especially valued for its spore-forming ability, which allows it to survive gastric acidity and reach the intestines intact. Once in the gut, B. clausii is believed to exert beneficial effects by competing with pathogens, producing antimicrobial substances, and modulating the immune response. A number of randomized controlled trials, particularly in pediatric populations, have shown that supplementation with B. clausii can reduce the duration and severity of diarrhea episodes associated with enteritis of various etiologies, including rotavirus and antibiotic use.

Guidelines from organizations such as the World Gastroenterology Organisation and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) mention B. clausii as one of the probiotics with some evidence for efficacy in acute infectious diarrhea. However, the magnitude of the benefit is generally modest, and not all studies are positive. Therefore, while scientific validation exists, further research is warranted to fully establish its clinical effectiveness and optimal use protocols.

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