Evidence supporting the use of: Vitamin B6
For the health condition: Energy (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin involved in numerous physiological processes, including amino acid metabolism, neurotransmitter synthesis, and hemoglobin formation. The rationale for using vitamin B6 to support energy largely stems from its biochemical role as a coenzyme in pathways that generate cellular energy, particularly through its involvement in the metabolism of proteins, carbohydrates, and fats. Deficiency in vitamin B6 can lead to symptoms such as fatigue, irritability, and confusion, which may improve upon supplementation.

However, scientific evidence supporting vitamin B6 supplementation specifically for treating general “lack of energy” in otherwise healthy individuals is limited. Clinical studies typically show that B6 supplementation benefits those who are deficient, but there is little robust evidence that additional B6 improves energy levels in people with adequate intake. Some studies have explored B-complex vitamins (including B6) in populations with fatigue, but results are often inconclusive or confounded by other nutrients.

Historically, vitamin B6 has been included in multivitamin and energy-support supplements based on its metabolic roles and the observation that deficiency can cause fatigue. However, for the general population with no deficiency, the effect of extra B6 on energy levels is minimal. Therefore, the use of vitamin B6 for energy is scientifically justified only in cases of deficiency, and the overall evidence for supplementation in the context of non-specific fatigue or lack of energy is weak (rated 2 out of 5).

More about vitamin B6
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Other ingredients used for Energy (lack of)

1,3,7-Trimethylpurine-2,6-dione
7-Keto-DHEA
Acai berry
Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Agastache
Akebia
Algae
Algal protein
Almond fruit
Alpha D-ribofuranose
Alpha polylactate
alpha-ketoglutarate (AKG)
alpinia galangal
amino acids
Amor seco
anamu
animal protein
antler
Aralia
Ardisia
Areca
arginine creatine
Arginine malate
Arginine silicate
ashwagandha
aspartic acid
atractylone
ba ji tian
banana
baobab
bee pollen
Beef liver
berry
beta phenethylalamine
beta-alanine
beta-hydroxybutyrate
biotin
black ginger
black pepper
blackthorn
Borassus aethiopum
borassus palm
borneol
bovine protein
bасора
caffeine
capsaicinoids
catecholamine
chia seed
Chlorophytum
chuchuhuasi
Cinnamomum
cistanche
coca
coconut
coconut milk
coconut oil
Codonopsis
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
cola nut
commiphora
cordyceps
creatine monohydrate
curcumen
Cynomorium
D-Ribose
deer root
deer velvet
Dendrobium
dextrates
dextrose
dragonhead
ecdysterone
egg
Egg protein
electrolytes blend (proprietary)
eleuthero
elk antler
ephedrine
Erodium cicutarium
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Eurycoma Longifolia
eurycomanone
folate
fungus
gamma-butyrobetaine
garden cress
ginseng
glucose
GMS-ribose
greens blend (proprietary)
guarana
Guaranine
guayusa
Herb Robert
Higenamine
Ilex
jiaogulan
jungli-bean
ketone salts
ketosterones
kola nut
L-alanyl-L-glutamine
l-carnitine
L-glutamine
L-glycine
L-leucine
l-tyrosine
lemongrass
lipids
maca
macaenes
macamides
magnesium
malic acid
maral root
medium chain triglycerides (MCT)
Methylliberine
Microbial enzymes (proprietary)
Milk
Milk Protein
Ming Dang Shen
Mushroom
Nettle
Orchis latifolia
ornithine L-aspartic acid
Oroxylum indicum
Osha
oxaloacetic acid
pantothenic acid (vitamin B5)
paraxanthine
peanut
Petiveria
Phytoecdysteroid
Plankton
pollen
Polygonatum
protein
Pseudostellaria
pyrroloquinoline disodium salt
pyrroloquinoline quinone
Rhodiola
ribose
robusta coffee
rosemary
Rubia yunnanensis
Rubiaceae
Safed musli
sage
Sarivan
shiitake mushroom
Sichuan Lovage
Sida cordifolia
siler root
Southern Tsangshu
Sphaeranthus indicus
spirulina
succinic acid
Sulbutiamine
suma
sweet flag
Synephrine
Tea
Teacrine
Terminalia
Theacrine
Theobromine
Thylakoid
Tongkat ali
trace minerals
Trichilia catigua
Trichopus zeylanicus
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
Wheat
wheat germ
Whey protein
Wulinshen
Yerba mate
Yuzu
Zedoary
Zinc
Zingiberene

Products containing vitamin B6

Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave