Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 (cyanocobalamin) is scientifically validated for use in treating fatigue and lack of energy, but only in specific contexts, notably when energy deficiency is caused by a B12 deficiency. Vitamin B12 is essential for normal neurological function and the formation of red blood cells. Deficiency can result in megaloblastic anemia, a condition characterized by fatigue, weakness, and reduced energy. Supplementation with B12 reliably reverses these symptoms in deficient individuals, which is well documented in clinical literature (O'Leary & Samman, 2010). However, in people with normal B12 levels, there is little scientific evidence that supplementation improves energy or alleviates fatigue. Randomized controlled trials in non-deficient populations do not show a significant effect of supplemental B12 on energy or fatigue. The widespread use of B12 supplements for "energy" in the general population is thus not supported by scientific evidence unless deficiency is present. In summary, there is robust evidence supporting B12’s use for restoring energy in cases of deficiency, but little to no evidence for benefit in those with adequate levels. Routine supplementation for energy in non-deficient individuals is not scientifically validated.

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