Evidence supporting the use of: Theacrine
For the health condition: Energy (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Theacrine is a purine alkaloid structurally similar to caffeine, primarily found in the Camellia assamica var. kucha tea plant. Its use for supporting energy and reducing fatigue has scientific validation, though the evidence base is still emerging and not as robust as for caffeine. Several small human studies have shown that theacrine supplementation (commonly as TeaCrine®) can improve subjective feelings of energy, alertness, and motivation to exercise, with effects noted both acutely and after repeated use. For example, a randomized, double-blind, placebo-controlled trial (Taylor et al., 2016) found that doses of 200-300 mg increased self-reported energy and reduced fatigue without causing significant habituation or tolerance over 7 days. Other studies indicate it may have less impact on blood pressure and heart rate compared to caffeine, potentially making it a preferable option for some users. However, most research to date involves small sample sizes, short durations, and sometimes industry sponsorship. There are also limited data on long-term safety and efficacy. Overall, theacrine appears to have some scientific support for enhancing energy and reducing fatigue, but the quality and quantity of evidence are moderate at best. More large-scale, independent, and long-term studies are needed to fully establish its efficacy and safety for this use.
Other ingredients used for Energy (lack of)
7-Keto-DHEAacai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
l-alanyl-l-glutamine
l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
Acetyl-L-Tyrosine
nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
rhodiola
rosemary
sage
shiitake mushroom
black ginger
sphaeranthus indicus
spirulina
succinic acid
tongkat ali
almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
whey protein
zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
yerba mate
wheat germ
algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
akebia
Alpha polylactate
Antler
Agastache
Arginine Creatine
Ardisia
Arginine malate
Anamu
Areca
adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
Atractylone
Animal protein
Beta Phenethylalamine
Blackthorn
Beta-hydroxybutyrate
Beef liver
Bovine Protein
berry
Ba Ji Tian
Borassus Palm
Borassus aethiopum
banana
Baobab
Borneol
Chia seed
Coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
Catecholamine
Chlorophytum
Chuchuhuasi
Curcumen
Coca
Chicken
cola nut
Dendrobium
Deer Root
Deer Velvet
Dragonhead
Dextrates
D-Ribose
Dextrose
Erodium cicutarium
Egg
Elk antler
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Egg protein
Ketone Salts
Milk Protein
peanut
Wheat
Other health conditions supported by Theacrine
Athletic and Exercise AidsConcentration (poor)
Energy (lack of)
Fatigue