Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Succinic acid is a naturally occurring dicarboxylic acid involved in the Krebs cycle (also known as the citric acid cycle or TCA cycle), which is central to cellular energy production in humans. The theoretical rationale for using succinic acid to support energy stems from its role as an intermediate in this cycle, which converts nutrients into ATP, the cell’s main energy currency. Some proponents claim that supplemental succinic acid can enhance energy levels or combat fatigue by supporting mitochondrial function.

However, scientific evidence for the efficacy of succinic acid supplementation in treating or preventing lack of energy or fatigue in humans is limited. While a few animal studies and in vitro experiments suggest that succinic acid may influence energy metabolism or protect against some forms of metabolic stress, robust clinical trials in humans are lacking. Existing studies are either small, not well-controlled, or focus on related compounds (such as succinate salts) rather than pure succinic acid. As a result, the evidence rating is low (2/5), reflecting plausible biological rationale but insufficient clinical validation.

Currently, succinic acid is found in some dietary supplements marketed for energy or anti-fatigue, but its use is not widely supported by major health authorities. Further research, particularly well-designed human trials, is needed to clarify its role and potential benefits in energy metabolism and fatigue management.

More about succinic acid
More about Energy (lack of)

Other ingredients used for Energy (lack of)

Other health conditions supported by succinic acid

Products containing succinic acid