Relationship: Energy (lack of) and pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Energy (lack of)

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Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (vitamin B5) is an essential water-soluble vitamin involved in many metabolic pathways, most notably as a component of coenzyme A (CoA), which is critical for the metabolism of carbohydrates, fats, and proteins to generate cellular energy (ATP). This biochemical role provides a scientific rationale for its association with energy production. Severe deficiency in pantothenic acid is rare but can result in symptoms such as fatigue, apathy, and irritability (historically described as "burning feet syndrome"). However, clinical studies in otherwise healthy individuals have not shown that supplementation with pantothenic acid above the recommended dietary allowance improves energy levels, reduces fatigue, or enhances athletic performance. Most people obtain adequate amounts of pantothenic acid from a varied diet, making overt deficiency uncommon.

While the essentiality of pantothenic acid for normal energy metabolism is well established scientifically, there is a lack of robust clinical evidence supporting its use as a treatment for general fatigue or low energy in the absence of deficiency. Thus, while its use is sometimes promoted for "energy support," this is primarily extrapolated from its biochemical necessity rather than direct evidence of benefit in supplementation. The evidence rating is therefore moderate (2/5), reflecting clear biochemical importance but limited clinical trial support for treating lack of energy in the general population.

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Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Energy (lack of)

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Evidence supporting the use of: Pantothenic acid (vitamin B5)For the health condition: Energy (lack of)

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Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Energy (lack of)