Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylliberine is a purine alkaloid structurally related to caffeine and theacrine, and is commonly marketed under the name "Dynamine." Its use as an energy-supporting ingredient is primarily based on its structural similarity to caffeine and preliminary research indicating that it may exert stimulant-like effects. Limited scientific studies, including a few small-scale human trials, suggest that methylliberine may increase subjective feelings of energy, alertness, and mood without significantly raising blood pressure or heart rate. For example, a 2019 human study found that methylliberine, alone or in combination with caffeine, was well-tolerated and led to modest increases in self-reported energy and focus. However, the body of evidence is still small, with few published peer-reviewed clinical trials and a lack of long-term safety data.

Unlike caffeine, methylliberine is not as extensively studied, and its mechanisms of action are not fully understood. Most available evidence comes from in vitro or animal studies, or from industry-sponsored research. While these early findings are promising and support its use for promoting feelings of energy, the overall quality and quantity of evidence is low. Therefore, while there is some scientific validation for the use of methylliberine to support energy, it is not robust, and the strength of evidence is rated as 2 out of 5.

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