Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-alanyl-L-glutamine is a dipeptide composed of the amino acids L-alanine and L-glutamine, designed to improve the stability and solubility of glutamine for supplementation. Its primary use in clinical and sports settings is to support hydration, intestinal health, and recovery from physical stress, rather than directly addressing lack of energy. However, there is some scientific rationale for its use related to energy, particularly in the context of exercise and recovery.

Several studies have investigated L-alanyl-L-glutamine’s effects on endurance athletes. Research indicates it may help maintain plasma glutamine levels during prolonged exercise, which can become depleted and potentially contribute to fatigue. Glutamine is involved in gluconeogenesis (the generation of glucose from non-carbohydrate sources) and supports the immune system, both of which are important for sustained performance and recovery. One randomized trial found that athletes supplementing with L-alanyl-L-glutamine had improved time to exhaustion and better fluid absorption, which could indirectly support energy levels during prolonged activity (Hoffman et al., 2010).

Despite these findings, the evidence is not robust or specific enough to conclude that L-alanyl-L-glutamine directly treats or cures general lack of energy, such as chronic fatigue or non-exercise-related tiredness. Most benefits appear limited to physical performance and recovery contexts. Therefore, while there is scientific investigation and some supportive data, the overall evidence for its use specifically for "energy (lack of)" is limited and rated as 2 out of 5.

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