Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Guaranine is the principal active compound found in guarana (Paullinia cupana), and it is chemically identical to caffeine. Its use to support or treat lack of energy is scientifically validated, as caffeine is a well-studied central nervous system stimulant. Numerous clinical studies have demonstrated that caffeine increases alertness, reduces perceived fatigue, and can temporarily enhance both cognitive and physical performance. The effects of guaranine are attributed to its ability to block adenosine receptors in the brain, thereby reducing drowsiness and increasing the release of neurotransmitters such as dopamine and norepinephrine.

Guarana extract, which contains guaranine, has been used traditionally by indigenous peoples of the Amazon for its stimulant effects, but modern research primarily attributes its energizing effects to its caffeine content. Randomized controlled trials have shown that guarana supplementation can improve attention and reduce mental fatigue in healthy adults. Systematic reviews generally support the use of caffeine-containing products for short-term enhancement of energy and alertness, though individual responses vary, and excessive intake can lead to side effects such as insomnia, anxiety, and increased heart rate.

In summary, the use of guaranine for combating lack of energy is supported by robust scientific evidence, largely due to its caffeine content and well-understood mechanisms of action.

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