Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine and leucine are both well-studied dietary supplements, particularly in the context of sports nutrition and energy metabolism. Creatine is one of the most widely researched ergogenic aids for improving energy availability, especially during short, high-intensity activities. It functions by increasing phosphocreatine stores in muscle, which helps regenerate ATP, the primary energy currency of cells, during periods of rapid energy demand. Numerous randomized controlled trials have demonstrated that creatine supplementation can reduce fatigue and improve performance in both athletic and some clinical populations with muscle weakness or fatigue.

Leucine, an essential branched-chain amino acid (BCAA), plays a critical role in stimulating muscle protein synthesis and may help reduce muscle breakdown during periods of stress or exertion. While leucine is less directly involved in immediate energy production than creatine, it can indirectly support energy by promoting muscle maintenance and recovery. There is some evidence that BCAA supplementation (including leucine) may help reduce perceived fatigue during prolonged exercise, though findings are mixed and the effect is generally modest.

Overall, the combination of creatine and leucine is scientifically validated for supporting energy—primarily in the context of exercise performance and muscle recovery. However, their use for treating general "lack of energy" (such as fatigue not related to exercise or muscle metabolism) is less well-established. The evidence rating of 4 reflects strong support for athletic contexts, but more limited evidence for broader fatigue conditions.

More about Creatine leucine
More about Energy (lack of)

Other ingredients used for Energy (lack of)

7-Keto-DHEA
acai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
l-alanyl-l-glutamine
l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
Acetyl-L-Tyrosine
nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
rhodiola
rosemary
sage
shiitake mushroom
black ginger
sphaeranthus indicus
spirulina
succinic acid
tongkat ali
almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
whey protein
zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
yerba mate
wheat germ
algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
akebia
Alpha polylactate
Antler
Agastache
Arginine Creatine
Ardisia
Arginine malate
Anamu
Areca
adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
Atractylone
Animal protein
Beta Phenethylalamine
Blackthorn
Beta-hydroxybutyrate
Beef liver
Bovine Protein
berry
Ba Ji Tian
Borassus Palm
Borassus aethiopum
banana
Baobab
Borneol
Chia seed
Coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
Catecholamine
Chlorophytum
Chuchuhuasi
Curcumen
Coca
Chicken
cola nut
Dendrobium
Deer Root
Deer Velvet
Dragonhead
Dextrates
D-Ribose
Dextrose
Eurycomanone
Erodium cicutarium
Egg
Elk antler
Eurycoma Longifolia
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Egg protein
Gamma-Butyrobetaine
GMS-ribose
glucose
Guaranine
Garden Cress
Ketone Salts
Milk Protein
peanut
Shellfish
Wheat

Other health conditions supported by Creatine leucine

Athletic and Exercise Aids
Energy (lack of)
Muscle Tone (lack of)
Wasting

Products containing Creatine leucine

We currently have no products on Caring Sunshine that contain this ingredient.