Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline alpha-ketoglutarate (CAKG) is a compound that combines the amino acid citrulline with alpha-ketoglutarate, a key intermediate in the Krebs (citric acid) cycle. Both constituents have been studied individually for their potential impact on energy metabolism and exercise performance.

Citrulline is known to increase plasma arginine levels, which may enhance nitric oxide (NO) production, leading to improved blood flow and nutrient delivery to working muscles. Some clinical studies with citrulline malate—a related compound—have shown modest improvements in exercise capacity, reduced fatigue, and better recovery in both aerobic and anaerobic exercise settings. However, the direct evidence for CAKG specifically is limited.

Alpha-ketoglutarate may play a role in cellular energy production as part of the Krebs cycle, but little human research exists regarding its supplementation and energy levels.

Overall, while there is some mechanistic rationale and indirect evidence (primarily from citrulline malate studies) suggesting a possible benefit for energy and exercise performance, the evidence supporting CAKG for treating or supporting general "lack of energy" is weak and mostly extrapolated. No large, high-quality clinical trials have specifically evaluated CAKG for this purpose. Therefore, the scientific evidence is limited (rated 2/5), and further research is needed to confirm any benefits.

More about Citrulline alpha-ketoglutarate
More about Energy (lack of)

Other ingredients used for Energy (lack of)

7-Keto-DHEA
acai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
aspartic acid
beta-alanine
biotin
black pepper
bасора
caffeine
capsaicinoids
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
eleuthero
folate
fructose
ginseng
greens blend (proprietary)
guarana
guayusa
l-alanyl-l-glutamine
l-carnitine
l-glutamine
l-glycine
l-leucine
l-tyrosine
maca
magnesium
malic acid
maltodextrin
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
milk
Acetyl-L-Tyrosine
nettle
pantothenic acid (vitamin B5)
pollen
protein
pyrroloquinoline disodium salt
rhodiola
rosemary
sage
shiitake mushroom
black ginger
sphaeranthus indicus
spirulina
succinic acid
tongkat ali
almond fruit
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
whey protein
zinc
suma
jiaogulan
alpinia galangal
commiphora
bee pollen
lemongrass
siler root
cistanche
sweet flag
electrolytes blend (proprietary)
trace minerals
yerba mate
wheat germ
algae
1,3,7-Trimethylpurine-2,6-dione
Aralia
akebia
Alpha polylactate
Antler
Agastache
Arginine Creatine
Ardisia
Arginine malate
Anamu
Areca
adenosine triphosphate (ATP)
Algal protein
Amor seco
Arginine silicate
Atractylone
Animal protein
Beta Phenethylalamine
Blackthorn
Beta-hydroxybutyrate
Beef liver
Bovine Protein
berry
Ba Ji Tian
Borassus Palm
Borassus aethiopum
banana
Baobab
Borneol
Chia seed
Coconut
Cinnamomum
Coenzyme A
coconut oil
Codonopsis
Cynomorium
Catecholamine
Chlorophytum
Chuchuhuasi
Curcumen
Coca
Chicken
cola nut
Dendrobium
Deer Root
Deer Velvet
Dragonhead
Dextrates
D-Ribose
Dextrose
Eurycomanone
Erodium cicutarium
Egg
Elk antler
Eurycoma Longifolia
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Egg protein
Gamma-Butyrobetaine
GMS-ribose
glucose
Garden Cress
Ketone Salts
Milk Protein
peanut
Shellfish
Wheat

Other health conditions supported by Citrulline alpha-ketoglutarate

Athletic and Exercise Aids
Body Building
Circulation (poor)
Energy (lack of)
Fatigue
Hypertension

Products containing Citrulline alpha-ketoglutarate

We currently have no products on Caring Sunshine that contain this ingredient.