Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aspartic acid is a non-essential amino acid involved in many biochemical processes, including the citric acid cycle and the synthesis of other amino acids. Its role in energy metabolism has led to its inclusion in some dietary supplements marketed to combat fatigue or low energy. There is some scientific rationale for this use, as aspartic acid participates in the malate-aspartate shuttle, which helps transport reducing equivalents (NADH) into the mitochondria for ATP production. Animal studies and in vitro experiments have demonstrated that aspartic acid supplementation can influence energy metabolism, and a few small human studies (primarily with the salt form, D-aspartic acid) have explored its effects on fatigue and physical performance.

However, the clinical evidence supporting aspartic acid supplementation for improving energy levels in humans is limited and not robust. Most studies are small, short-term, or focus on athletic performance rather than general fatigue or lack of energy. There are also conflicting results regarding its efficacy. While the theoretical basis for aspartic acid in supporting energy is valid, and there is some preliminary scientific evidence, there is not enough high-quality clinical data to justify strong claims for its effectiveness in treating or preventing energy deficiency in the general population.

In summary, aspartic acid has a scientifically plausible mechanism and limited preliminary support for use in energy metabolism, but the current evidence base is weak, justifying a rating of 2 out of 5.

More about aspartic acid
More about Energy (lack of)

Other ingredients used for Energy (lack of)

Other health conditions supported by aspartic acid

Products containing aspartic acid

Nature's Sunshine Free Amino Acids