Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Peptides, particularly certain bioactive peptides and peptide-based drugs, have garnered scientific interest for their potential role in supporting or improving endurance. One of the most studied categories is growth hormone secretagogues such as Ipamorelin, CJC-1295, and other related peptides, which stimulate the release of growth hormone. This, in turn, may enhance recovery, lean muscle mass, and possibly endurance by improving tissue repair and energy metabolism. Additionally, some peptides like beta-alanine peptides are precursors to carnosine, a molecule known to buffer muscle acidity and delay fatigue during high-intensity exercise.

Clinical evidence in humans is still emerging. A handful of small-scale studies and animal research suggest that peptide supplementation or peptide hormones can modestly improve exercise performance, increase time to exhaustion, and reduce muscle damage markers. However, these findings are not yet robust or consistent across larger, controlled trials. Moreover, safety and long-term effects remain under investigation, and many peptide products marketed for endurance have not been evaluated by regulatory bodies for efficacy or safety.

In summary, while there is scientific rationale and some early empirical evidence supporting the use of certain peptides for endurance, the overall quality and quantity of evidence is moderate and not yet conclusive. Use outside of clinical supervision is not widely recommended.

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