Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Squaw Vine (Mitchella repens) has a long history of use in traditional herbal medicine, especially among Indigenous peoples and early North American herbalists. Its primary reputation is as a "parturient" or uterine tonic, used to support women’s reproductive health, particularly in preparing for childbirth and relieving menstrual discomfort. However, there is no direct traditional documentation specifically linking Squaw Vine to the treatment of endometriosis. Rather, its use has been generalized for "female complaints," which some herbalists have extrapolated to cover a broad range of gynecological issues, including endometriosis. Scientifically, there is a lack of clinical or preclinical research validating the efficacy of Squaw Vine for endometriosis; no studies have demonstrated anti-inflammatory, analgesic, or hormone-modulating effects relevant to this condition. Its use for endometriosis in modern herbalism is based on tradition and anecdotal reports, not on robust scientific evidence. Thus, while Squaw Vine is sometimes included in herbal blends aimed at uterine health, its specific application to endometriosis is justified primarily by tradition, and the supporting evidence is minimal.

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