Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols are a broad class of plant-derived compounds found in foods such as fruits, vegetables, tea, coffee, and wine. Their use in supporting or treating endometriosis is primarily based on emerging scientific evidence rather than traditional medicine. Some preclinical studies and limited clinical data suggest that polyphenols possess anti-inflammatory, antioxidant, and anti-angiogenic properties, which are relevant to endometriosis—a condition characterized by inflammation and abnormal tissue growth outside the uterus. Specific polyphenols, such as resveratrol (found in grapes and berries), epigallocatechin gallate (EGCG, from green tea), and curcumin (from turmeric), have been investigated for their effects on endometriosis in laboratory and animal models. These studies show that polyphenols may inhibit the growth of endometrial lesions, reduce inflammation, and modulate immune responses.

However, human clinical research is limited and often involves specific polyphenols rather than generic "polyphenols (unspecified)." Existing clinical trials are small, and results are not always consistent. There is not yet strong, high-quality evidence to recommend polyphenols as a standard treatment for endometriosis, but the scientific rationale for their potential benefit exists. In summary, while there is a scientific basis for considering polyphenols in endometriosis support, the current evidence is preliminary, and their use should be regarded as adjunctive pending further research.

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