Evidence supporting the use of: Diclofenac
For the health condition: Endometriosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is scientifically validated for use in the management of pain associated with endometriosis. Endometriosis often causes significant pelvic pain due to inflammation and the presence of endometrial tissue outside the uterus. Diclofenac works by inhibiting the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins—lipid compounds that mediate inflammation and pain. Multiple clinical guidelines and reviews, including those from the European Society of Human Reproduction and Embryology (ESHRE), recommend NSAIDs like diclofenac as first-line therapy for the symptomatic management of endometriosis-related pain, especially dysmenorrhea (painful menstruation).

However, while NSAIDs such as diclofenac are effective for symptomatic pain relief, they do not treat the underlying endometrial lesions or stop disease progression. The overall quality of evidence supporting NSAIDs for pain relief is moderate, with randomized controlled trials and systematic reviews demonstrating efficacy superior to placebo, but not always clearly superior to other NSAIDs or analgesics. Side effects and contraindications, particularly gastrointestinal or cardiovascular risks, must also be considered. In summary, diclofenac is scientifically validated and widely used for pain relief in endometriosis, but is not a disease-modifying treatment.

More about Diclofenac
More about Endometriosis

Products containing Diclofenac

We currently have no products on Caring Sunshine that contain this ingredient.