Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcuminoids, the active compounds found in turmeric (Curcuma longa), have been investigated for their potential role in supporting or treating endometriosis. The primary justification for their use is scientific, though the overall quality and quantity of evidence is limited, warranting a moderate-low evidence score of 2.

Endometriosis is characterized by inflammation, abnormal tissue growth, and pain. Curcuminoids, especially curcumin, are known for their anti-inflammatory, antioxidant, and anti-proliferative effects. Several preclinical studies (cell culture and animal models) have demonstrated that curcumin may inhibit the growth and invasion of endometrial cells, modulate immune responses, and reduce the expression of pro-inflammatory cytokines relevant to endometriosis. For example, curcumin has been shown to downregulate NF-κB activity and reduce levels of TNF-α, IL-1β, and IL-6 in experimental models, which are key mediators of inflammation in endometriosis.

However, clinical trials in humans are scarce. Most available studies are preclinical; only a few small human studies or case reports exist, and these typically lack rigorous methodology or sufficient sample sizes to draw strong conclusions. Therefore, while there is a scientific rationale and encouraging preclinical data supporting curcuminoids' potential in endometriosis management, high-quality human research is needed to confirm efficacy and safety.

More about Curcuminoid (unspecified)
More about Endometriosis

Other ingredients used for Endometriosis

Other health conditions supported by Curcuminoid (unspecified)

Products containing Curcuminoid (unspecified)