Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have garnered considerable scientific attention for their role in supporting emotional well-being and modulating emotional sensitivity. Several randomized controlled trials and meta-analyses suggest that omega-3 supplementation can have a modest but significant effect on mood regulation, especially in populations with mood disorders such as depression, which can overlap with symptoms of emotional sensitivity.

The biological rationale centers on the anti-inflammatory properties of omega-3s, their role in cell membrane fluidity in neuronal cells, and their involvement in neurotransmitter function. Some studies indicate that low omega-3 status is associated with increased emotional reactivity and mood disturbances. Supplementation with omega-3s, particularly those with higher EPA content, has been shown to reduce symptoms of depression, irritability, and emotional lability in some individuals, although results are mixed and effect sizes are generally small to moderate.

While the evidence is strongest for mood disorders, the overlap of emotional sensitivity with conditions such as depression and anxiety means that omega-3 supplementation is sometimes used by clinicians to help stabilize mood and reduce emotional volatility. However, more targeted research is needed to confirm the efficacy of omega-3s specifically for emotional sensitivity outside the context of clinical mood disorders.