Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ursane-type triterpenoids, such as ursolic acid, are primarily justified for use in treating or supporting edema based on traditional medicine rather than robust scientific validation. These compounds are abundant in various medicinal plants, such as Centella asiatica (Gotu Kola) and Prunella vulgaris, which have a long history of use in traditional systems such as Ayurveda, Traditional Chinese Medicine (TCM), and folk medicine for the management of swelling and inflammation, which can include edema. The traditional rationale is that ursane-type triterpenoids possess anti-inflammatory and diuretic properties, which may help reduce fluid retention and tissue swelling. Some preclinical studies (in vitro and animal models) suggest that ursolic acid can exert anti-inflammatory effects by inhibiting pro-inflammatory mediators and modulating vascular permeability, which could theoretically benefit edema. However, direct clinical evidence in humans specifically demonstrating efficacy for edema is lacking. There are no high-quality randomized controlled trials that confirm the use of ursane-type triterpenoids for the treatment of edema. Therefore, while their use for edema is rooted in traditional practice and supported by limited mechanistic and animal data, the evidence base is weak, and the triterpenoids should not be considered a scientifically validated treatment for edema at this time.

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