Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Pluchea, particularly Pluchea indica and Pluchea lanceolata, has a longstanding history of use in traditional medicine systems such as Ayurveda and Thai folk medicine for the management of edema and inflammatory conditions. Traditional practitioners have utilized decoctions and extracts from leaves and roots to promote diuresis—an increase in urine output—which is believed to help reduce fluid accumulation associated with edema. The use for this purpose is documented in several ethnobotanical surveys and traditional pharmacopeias.

Scientific investigation into Pluchea’s anti-edematous effects is limited, but some preclinical studies in animal models suggest diuretic and anti-inflammatory properties. For example, extracts of Pluchea indica have demonstrated significant diuretic activity in rats, comparable to mild conventional diuretics. These effects are attributed to phytochemicals such as flavonoids and terpenes, which may modulate inflammatory pathways and influence renal excretion of water and electrolytes. However, robust clinical trials in humans are lacking, and the overall quality of evidence remains low. As such, while its use for edema is justified by tradition and supported by preliminary animal research, definitive scientific validation is not yet established.

In summary, Pluchea’s use for edema is rooted in traditional medicine with some supportive, but limited, scientific evidence primarily from animal studies.

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