The use of Loranthus species (commonly known as mistletoe) for the treatment of edema is supported primarily by traditional medicine practices rather than robust scientific evidence. In various traditional medicinal systems, especially within Indian, African, and Southeast Asian ethnomedicine, Loranthus has been used as a diuretic and for the management of swelling or water retention, which are symptomatic of edema. Traditional healers have employed different parts of the plant—especially leaves and stems—to prepare decoctions or infusions believed to promote urination and thus reduce fluid accumulation in the tissues.

However, scientific studies specifically examining the anti-edematous or diuretic effects of Loranthus are sparse. A few phytochemical and pharmacological investigations have identified the presence of bioactive compounds such as flavonoids, tannins, and saponins that may have mild diuretic effects in animal models, but these studies are preliminary and not directly linked to clinical management of edema. There is no high-quality clinical trial data supporting its efficacy or safety for this indication. Therefore, while its use is deeply rooted in tradition, the scientific validation is limited, and further research is needed to confirm any therapeutic benefit for edema.