Curcumen, a compound found in Curcuma species such as Curcuma zedoaria and Curcuma longa (turmeric), has a long history of use in traditional medicine systems, particularly in Ayurveda and Traditional Chinese Medicine (TCM). Historically, extracts from Curcuma species have been used to address swelling, inflammation, and disorders associated with water retention, which are symptomatic of edema. The rationale in these traditions is often linked to Curcuma’s reputed abilities to "move blood," reduce "dampness," or "invigorate circulation." However, the scientific evidence specifically linking Curcumen or related Curcuma extracts directly to the treatment or reduction of edema in humans is limited. Most contemporary studies focus on curcumin (a different, though related, compound) and its anti-inflammatory properties. Some animal studies and in vitro experiments suggest that Curcuma extracts may inhibit inflammatory mediators and reduce vascular permeability, which could theoretically reduce edema. Still, rigorous clinical trials specifically evaluating Curcumen’s efficacy for edema are lacking. As a result, while the traditional use of Curcumen for edema is well-documented and persists in herbal practice, the scientific evidence to support its effectiveness for this purpose remains preliminary. More robust clinical research would be needed to substantiate its use beyond traditional contexts.