The use of Cucurbita species (such as pumpkin and squash) for supporting or treating edema is primarily rooted in traditional medicine rather than robust scientific evidence. In several traditional systems, particularly in Asian countries and some parts of Europe, seeds, pulp, and other parts of Cucurbita plants have been used as mild diuretics to help reduce water retention and swelling associated with edema. Historical texts sometimes mention the consumption of pumpkin flesh or seeds as a food remedy for "dropsy," an old term for edema. However, these uses are largely based on folk practice and anecdotal evidence rather than systematic clinical studies.

Regarding scientific validation, there is very limited research specifically examining the diuretic effects of Cucurbita species in the context of edema. Some animal studies suggest mild diuretic activity, but results are not consistent, and there is a lack of high-quality clinical trials in humans. Most modern evidence focuses on other properties of Cucurbita (such as its role in prostate health or as a source of nutrients), rather than its impact on fluid retention. Therefore, while Cucurbita has a historical basis for use in edema, it cannot be considered scientifically validated for this indication.